Luciano et al., 2025 (N Engl J Med): A randomized, double-blind, placebo-controlled trial of shunt surgery was conducted among 99 participants having idiopathic normal pressure hydrocephalus (iNPH). It was observed that shunt surgery increases the gait velocity and was found unchanged in the placebo. A significant difference favoring shunt surgery […]
Estrella et al 2025(JAMA): A Meta-Analysis of 821327 outpatient participants and nearly 39 639 hospitalized patients who had both creatinine and cystatin C based eGFR measurements were conducted. Participants were followed for an average of 11 years to evaluate long term outcomes. The analysis showed that approximately 11% of outpatients and […]
Wharton et al., 2025 (N Engl J Med): In a phase 3 multinational, randomized, double-blind trial, Orforglipron, a small-molecule, nonpeptide GLP-1 receptor agonist, was investigated as a treatment for obesity. The safety and efficacy of orforglipron at doses (mg) of 6, 12, or 36 once-daily, as compared with placebo (assigned […]